Prostate Cancer Research and Treatment
For Karl Loren
Link to LIST of Dark Times Digests and Related Items
Karl Note: You can simply read straight down, or pick from the various segments listed below to jump back and forth between the segment and this top of the page.
Personal
1.1 Personal Vital Statistics: Daily Weight, BP and other
1.2 Karl's first indication that he might have prostate cancer
1.3 Karl's further Considerations after a few days of thought
1.4 Karl's final, and changing, total advice about his own treatment
1.5 Karl's Photo Slide Show -- Never Before Published
1.55 Or 1.12 OR SUCH Will be used to add items in the sequence and allow the existing number sequence to be relatively stable
1.6 eMail Exchanges With Karl and Subscribers about prostate health
1.7 LRH Quotes
Drugs
2.3 Solage liquid for skin conditions including skin cancer
2.x Additional Drug Information
Treatments:
3.1 PSA Test Official Government Data
3.2 "Official" FDA Description of this Prostate Health Problem
3.3 Prostate Cancer Treatment Choices
3.4 My About-Face on the PSA Test Why every man should have this prostate test done today!
3.5 FAKE Source of Data About Prostate Cancer
3.6 Suggestion From Karl's Close Friend Dr. MSR Ayyangar, Mumbai, India
3.8 Vitamin D3 as a previously under appreciated prevention of cancer.
3.81 Vitamin D -- More details on it as a cancer preventative
3.9 Q&A About PSA Scores -- Doctor's Answers
3.XX For additional items
Suggested Protocol
4.1 Karl Loren's Treatment Protocol
1.2 |
The start, with the tentative diagnosis and immediate Plan for Karl Loren Sent as an eMail to several people on 17 July 2009 I, Karl Loren, had a routine physical examination on July 3, 2009, with the schedule for receiving the results on July 17, 2009, the very day I start writing this page. While the results were "normal" and "not unusual" in all respects but one, that one gives me the motivation to write and publish this page. That result was a PSA reading of 15. Later that day I wrote the following message on Friday, July 17, 2009, to close friends, including Debbie, to give them some of the plan I expected to follow:
On Fri, Jul 17, 2009 at 10:14 AM, Debbie wrote: I understand and thank goodness you do. Too many people want small games. I was listening to a lecture Wed. night, where Ron says, if you don't learn anything learn Logic 6 and then the one after that which he emphasized was gradients. So we'll call it a gradient to get people more and more involved. Keep up the good work. ----- Original Message ----- Dear Debbie Take a look at: Karl Loren |
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1.3 |
Two Days After: Considerations and Thoughts Sunday, July 19, 2009 My first thought at hearing the "PSA 15" was that I recognized what the significance was -- that about 3 or 4 was OK, 5 was of concern and over 12 was serious. So, I first thought of this news as "serious," but in the same breath the doctor said "Prostate cancer hardly ever kills anyone -- they die of something else first, and it is also slow growing thing -- 10 years at least before it is ..." I don't know what he said, but my thought at this point was, "Well, that's enough time to do all the things that I have planned to do." Then I heard him say something like, "It gets very painful if not handled in time." That made me want to get further data on that. I looked. I found, instead, what I consider deceptive web mastering where some person figures he can sell advertising on a particular "phrase" such as "end stage prostate cancer."
Back to my thoughts and considerations. I conclude that "end stage prostate cancer" means the cancer has metastasized into the bones. I can understand how that might be painful, but the "watchful waiting" treatment I've already found HERE, suggests that regular PSA tests can indicate quickly enough, with a slow-growing cancer, if some treatment reduces the PSA test result -- thus indicating that the treatment, whatever it is, seems to be working. It seems now that I am in for understanding the PSA tests much better, how to get them and which of any treatments reduces those scores. After reading the government-sourced data about PSA tests, I conclude that the data is oriented very much, almost ONLY, toward using the PSA test for detecting CANCER, NOT for measuring the other possibility -- enlarged prostate gland. One small piece of good news in the government data was this:
As of now I am further confirmed in my initial choice of using "watchful waiting" while "treating" the PSA reading as indicating "cancer," but "treating whatever it is with nothing more than non-drug and non-surgery and non-radiation types of treatments. Another reference I found useful from the government data was this:
Another encouraging comment follows: These results suggest that many men were diagnosed with, and treated for, cancers that would not have been detected in their lifetime without screening and, as a consequence, were exposed to the potential harms of unnecessary treatments, such as surgery and radiation therapy. Nevertheless, it remains possible that a small benefit from the earlier detection of these “excess” cancers could emerge with longer follow-up. Follow-up of the PLCO participants will continue, therefore, until all participants have been followed for at least 13 years. (Source: Part of Answer to Question #9 here
The initial protocol is just as I have laid out in my first-day report to friends about what I expected to use -0- HERE.
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1.4 |
Karl's Final Summary and his Plan of Treatment -- Changing regularly August 2, 2009 Re: prostate test and other matters
Dr. D. W. Plance Phone 818.249.4134 Dear Dr Plance, I have good news to report, both about the prostate and my blood pressure. First, the BP:
Loren C. Troescher I’ve pasted in above some of the readings done today. They show, for each day, more so after the sample I sent to you by mail, SOME readings every day that were below 150/100, including one today, shown in bold type. I use the BP machine generally always with the same procedure: I measure while sitting at my desk, often cold because of the AC. Once I get a low reading, I typically repeat the test several times during the next few minutes. It appears that I can always get a reading at or below 150/100 by relaxing more or getting warm, or sitting “better” at the desk. It also seems that certain times of the day are more likely to produce lower scores. It seems to me that the new BP med is doing the job. On the prostate, another good report. After my first visit with Dr. Reynolds I gave blood and urine samples and understood from him that the blood test would measure the “free PSA” percentage and that 30% or higher would typically indicate no cancer while 11% or less would be indication of probable cancer. The blood test lab assured me that your name on the test request meant you would receive a copy. From Dr. Reynold’s rectal exam he described the prostate as very large but all soft with no hard parts. I do not seem to have any difficulty with urination. Night time frequency is not an issue when I sleep with my CPAK. I forgot to mention to him, or you, that I had a very painful removal of a catheter after a failed stent placement required me to stay in the hospital overnight about a year ago. The need for the catheter had not been anticipated, it had to be inserted and withdrawn with no sedation – very painful and it caused painful urination for some weeks. That symptom is now gone. My wife and I saw Dr. Reynolds last Friday to learn these test results. First, he said that I had come in with a blood test of PSA 15, and just exactly one week later, a second blood test showed that reading at 12 (I think that was the number). He said that there is a known phenomenon of a PSA score that rises and falls in a pattern, so that further PSA tests would probably reveal the high and low points of a continuing pattern. I didn’t get the exact significance of this “pattern,” but did get the idea that the fact that the score was significantly lower than a week earlier meant that there was considerably less to worry about with that reading, not so much that it was low (not so) but because it fluctuated. He next told us that the Free PSA was (I think he said) 15. That is not as high as the 30% score that indicates no cancer, but not as low as the 11% score that indicates a strong possibility of cancer. He said that he felt the chances of cancer were a small amount less than 50%, and he used the term, “watchful” and suggested I do nothing. No biopsy, and come back in several months for another Free PSA test – and to see if the prostate was larger or smaller. That is now scheduled for early December, with a copy of the test result for you. I was pleased with that opinion, told him so, and told him that I fully expected to pursue non-drug remedies. I described them to him == although I think he was simply polite and did not know about them, nor want to give any opinion. I told him my opinion about the dangers of a biopsy, causing a spread of cancer if there were any there. He (politely) disagreed, saying that there was no such danger relative to prostate – might be for other types of cancer, but not prostate – he then “threw in” that prostate was slow growing. I suspect that any lack of evidence of biopsy-caused spreading is missed simply because prostate cancer is so slow. I still would pursue other “serious” remedies” rather than move ahead with a biopsy or surgery or drugs. He also told me that he knew of a Prostate test of selenium, but that it turned out to not be as useful as people had hoped. I listen, but am taking 400 mcg of Selenium daily anyway. I am taking about 1-2 grams of pure germanium daily, and the equivalent of about 40 of the Taheebo capsules every day. I also take pycnogenol, grape seed extract, a Whole Foods prostate health formula. I have also studied about, and probably will use, “milking” the prostate to drain excess fluid and am willing to learn about other remedies you might suggest. The skin cancer usage of Solage seems to reduce the area of redness. One day I went some hours before application and it appeared to have “grown” to its earlier size. It seems to respond to the twice-daily application. I would be ready to get another bottle if this apparent improvement continues. I’ll call soon to find out if you think another visit to your office is called for.
Regards,
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| 1.7 |
"When you can be your own best audience and when your applause is the best applause you know of, you're in good shape. And when you can play a real good role — when you can go down here and be the mule or be the general with equal verve, in the total spirit of play, and do it with terrific sincerity — you're living!"
"The next time you think you're having an awful lot of trouble somewhere, well, just wonder whether or not you can't communicate with it. And if you communicated with it gently enough, it won't backfire hard. If you communicate and—miscalculate a little bit and communicate too much or too fast or with too much velocity, it's liable to come back and knock your head off. But that's all right, put your head back on and communicate again. That's always what you must do. The reason you stopped communicating in the first place is you lost a few heads, but what are heads? Expendable."
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2.1 |
Over time, AVODART can shrink the prostate. If left untreated, the prostate may continue to grow, and in some men lead to worsening urinary symptoms. The benefits of AVODART can include:
If you have Enlarging Prostate, talk to your doctor about shrinking it and ask if AVODART is right for you.
Teratogenic effect (Affect on pregnant women of male children who even touch these) The teratogenic effect from Dutasteride is a very large risk for male children. The effect would be similar to 5-alpha-reductase deficiency, where a developing male child naturally is deficient in 5-alpha reductase type 2, and thus unable to synthesize DHT Type 2. As Dutasteride blocks the same process (although type 1 and 2 DHT) a developing male would have this deficiency as a result of medication, rather than simply naturally. Women who are pregnant or in their childbearing years, and children, should be prevented from handling the capsules as inadvertent consumption may cause major birth defects. Another Source for Adverse Effects
Adverse EventsSourceTwenty-five percent (102/416) of subjects experienced a total of 169 adverse events that were classified by the investigator as having a reasonable possibility of being drug-related (7). Those drug-related adverse events having and incidence > 5% within any treatment group are presented in Tale 2.The most common drug-related adverse event were decreased lilbido experienced by 13% of subjects receiving Avodart 2.5 mg/day followed by headaches, experienced by 8% of the Avodart 0.1mg/day group and 6% by both the Avodart 0.5mg/day and 2.5 mg/day group. There were no serious adverse events that were considered drug-related. Partner PregnanciesFive partner pregnancies were reported during the study. One female partner spontaneously aborted (study subject was on placebo) and one had a partial placenta previa with subsequent delivery of a normal male infant (study subject was on Avodart 0.5 mg). The other three pregnancies were normal and resulted in the births of two males (two subjects on "Avodart 0.5mg and one on Avodart 2.5mg) and one female (subject on Avodart 2.5mg). None of the infants had genital or other abnormalities at birth (7). PrecautionAvodart Soft Gelatin Capsules should not be handled by a woman who is pregnant or who may become pregnant because of the potential for absorption of dutasteride and the subsequent potential risk to a developing male fetus. Avodart is contraindicated for use in women. Avodart has not been studied in women because preclinical data suggest that the suppression of circulation levles of dihydrotestosterone may inhibit the development of the external genital organs in a male fetus carried by a woman exposed to dutasteride (6) REV 0704Google Search Result (but the web demands your personal data before they will give the results claimed.) Drug interactions analysis of Avodart, Uroxatral for males aged 60 ...93 related reports are studied for females and males at all ages when co-using Avodart, Uroxatral: Comparison with the patient's adverse outcomes: ...
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2.2 |
Karl Note: I would certainly avoid using this drug -- first it is a "drug" when natural remedies, even "watchful waiting" seems better to me and second because of all the "side effects" which the drug maker does NOT include in his official warning. Mostly I find that even a person who wants to find the information I have on this page cannot find it without learning the tricks of the drug companies. They deliberately "own" OR "CREATE" dozens of web sites, different addresses, but hire expensive web designers, get high Google Search Engine Rankings and therefore these dominate the first 50 or so search results. I had to wade through dozens of these deceptive web sites, many of them simply selling the pill and repeating the company's lies. I, Karl Loren, not only research the drug itself, but the very method you might use to find out about it. Beware! The web is changing in favor of the drug industry, and Google goes along with it while the FDA promotes it. See my expose of the new FDA Commissioner whose job it is and will be to make it easier for drugs to hit the market and to hit you. Indication Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH. Important Safety Information Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir. UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates. Before taking UROXATRAL, tell your doctor if you have kidney problems. Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval. BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer. The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness. Official Instructions:
FDA Warning --Women should not use: alfuzosin hydrochloride or any component of UROXATRAL tablets.
WARNINGS
Postural hypotension with or without symptoms (e.g., dizziness) may develop within a few hours
following administration of UROXATRAL (alfuzosin HCl extended-release tablets). As with
other alpha-blockers, there is a potential for syncope. Patients should be warned of the possible
occurrence of such events and should avoid situations where injury could result should syncope
occur. There may be an increased risk of hypotension/postural hypotension and syncope when
taking UROXATRAL concomitantly with anti-hypertensive medication or nitrates. Care should
be taken when UROXATRAL is administered to patients with symptomatic hypotension or
patients who have had a hypotensive response to other medications.
General
Prostatic Carcinoma: Carcinoma of the prostate and BPH cause many of the same symptoms. These two diseases frequently coexist. Therefore, patients thought to have BPH should be examined prior to starting therapy with UROXATRAL (alfuzosin HCl extended-release tablets)
to rule out the presence of carcinoma of the prostate.
Intraoperative Floppy Iris Syndrome (IFIS): IFIS has been observed during cataract surgery
in some patients on or previously treated with alpha-1 blockers. This variant of small pupil
syndrome is characterized by the combination of a flaccid iris that billows in response to
intraoperative irrigation currents, progressive intraoperative miosis despite preoperative dilation
with standard mydriatic drugs, and potential prolapse of the iris toward the phacoemulsification
incisions. The patient’s ophthalmologist should be prepared for possible modifications to their
surgical technique, such as the utilization of iris hooks, iris dilator rings, or viscoelastic
substances.
There does not appear to be a benefit of stopping alpha-1 blocker therapy prior to cataract
surgery.
Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between UROXATRAL and other alpha-blockers have not been determined. However, interactions may
be expected, and UROXATRAL should NOT be used in combination with other alpha-blockers.
Coronary Insufficiency: If symptoms of angina pectoris should newly appear or worsen,
UROXATRAL should be discontinued.
Hepatic Insufficiency: UROXATRAL should not be given to patients with moderate or severe
hepatic insufficiency. (See CONTRAINDICATIONS). The pharmacokinetics of
UROXATRAL have not been studied in patients with mild hepatic insufficiency (See
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Renal Insufficiency: Systemic exposure was increased by approximately 50% in pharmacokinetic studies of patients with mild, moderate, and severe renal insufficiency (See
CLINICAL PHARMACOLOGY, Special Populations). In phase 3 studies, the safety profile of
patients with mild (n=172) or moderate (n=56) renal impairment was similar to the patients with
normal renal function in those studies. Safety data are available in only a limited number of
patients (n=6) with creatinine clearance below 30 mL/min; therefore, caution should be exercised
when UROXATRAL is administered in patients with severe renal insufficiency.
Patients with Congenital or Acquired QT Prolongation: In a study of QT effect in 45 healthy males (See CLINICAL PHARMACOLOGY, Electrophysiology), the QT effect
appeared less with alfuzosin 10 mg than with 40 mg, and the effect of alfuzosin 40 mg did not
appear as large as that of the active control moxifloxacin at its therapeutic dose. A post-
marketing study evaluating the effect of combining UROXATRAL with another drug of
comparable QT effect showed an increased effect when compared to either drug alone (see
CLINICAL PHARMACOLOGY, Electrophysiology). Although this study was not designed to make direct statistical comparisons between drugs, the QT increase with both drugs was no more
than additive and was lower than that of the active control moxifloxacin. These observations
should be considered in clinical decisions when prescribing UROXATRAL for patients with a
known history of QT prolongation or patients who are taking medications which prolong the QT
interval. There has been no signal of Torsades de Pointe in the extensive post-marketing
experience with alfuzosin. There are no known PK/PD studies of the effects of other alpha-
blockers on cardiac repolarization.
Information for Patients Patients should be told about the possible occurrence of symptoms related to postural
hypotension, such as dizziness, when beginning UROXATRAL, and they should be cautioned
about driving, operating machinery, or performing hazardous tasks during this period.
UROXATRAL should be taken with food and with the same meal each day.
Patients should be advised not to crush or chew UROXATRAL tablets.
Laboratory Tests
No laboratory test interactions with UROXATRAL tablets are known.
Pediatric Use
UROXATRAL is not indicated for use in children.
Geriatric Use Of the total number of subjects in clinical studies of UROXATRAL, 48% were 65 years of age
and over, whereas 11% were 75 and over. No overall differences in safety or effectiveness were
Carcinogenesis, Mutagenesis, and Impairment of Fertility
There was no evidence of a drug-related increase in the incidence of tumors in mice following
dietary administration of 100 mg/kg/day alfuzosin for 98 weeks (13 and 15 times the level of
exposure to humans based on AUC of unbound drug) in females and males, respectively. The
11 highest dose tested in female mice may not have constituted a maximally tolerated dose.
Likewise, there was no evidence of a drug-related increase in the incidence of tumors in rats
following dietary administration of 100 mg/kg/day alfuzosin for 104 weeks (53 and 37 times the
level of exposure to humans based on AUC of unbound drug) in females and males, respectively.
Alfuzosin showed no evidence of mutagenic effect in the Ames and mouse lymphoma assays,
and was free of any clastogenic effects in the Chinese hamster ovary cell and in vivo mouse
micronucleus assays. Alfuzosin treatment did not induce DNA repair in a human cell line.
There was no evidence of reproductive organ toxicity when male rats were given alfuzosin at
daily oral (gavage) doses of up to 250 mg/kg/day for 26 weeks, which corresponds to levels of
exposure several hundred times that in humans. No impairment of fertility was observed
following oral (gavage) administration to male rats at doses of up to 125 mg/kg/day for 70 days.
Estrous cycling was inhibited in rats and dogs at doses of 25 mg/kg and 20 mg/kg, respectively,
corresponding to levels of systemic exposure (based on AUC of unbound drug) 12- and 18-fold
higher, respectively, than in humans, although this did not result in impaired fertility in rats.
Pregnancy Teratogenic Effects, Pregnancy and Lactation Category B. UROXATRAL is not indicated
for use in women.
There was no evidence of teratogenicity or embryotoxicity in rats at maternal (oral gavage) doses
up to 250 mg/kg/day, corresponding to systemic exposure levels 1,200-fold higher than in
humans. In rabbits, up to the dose of 100 mg/kg/day (approximately 3 times the clinical dose by
body surface area) given orally (via gavage), no evidence of fetal toxicity or teratogenicity was
seen.
Gestation was slightly prolonged in rats with a maternal dose >5 mg/kg/day (oral gavage), which
corresponds to systemic exposure levels (based on AUC of unbound drug) 12 times higher than
human exposure levels, but there were no difficulties with parturition.
Nursing Mothers
UROXATRAL is not indicated for use in women.
ADVERSE REACTIONS
The incidence of treatment-emergent adverse events has been ascertained from 3 placebo-
controlled clinical trials involving 1,608 men in which daily doses of 10 and 15 mg alfuzosin
were evaluated. In these 3 trials, 473 men received UROXATRAL (alfuzosin HCl 10 mg
extended-release tablets). In these studies, 4% of patients taking UROXATRAL (alfuzosin HCl
extended-release tablets) 10 mg tablets withdrew from the study due to adverse events, compared
with 3% in the placebo group.
Table 4 summarizes the treatment-emergent adverse events that occurred in ≥2% of patients
receiving UROXATRAL, and at an incidence numerically higher than that of the placebo group.
In general, the adverse events seen in long-term use were similar in type and frequency to the
events described below for the 3-month trials.
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Table 4 — Treatment-Emergent Adverse Events Occurring in ≥2% of UROXATRAL- Treated Patients and More Frequently than with Placebo in 3-Month Placebo-Controlled
Clinical Studies
Adverse Event
Placebo
UROXATRAL
(n=678)
(n=473)
Dizziness
19 (2.8%)
27 (5.7%)
Upper respiratory tract infection
4 (0.6%)
14 (3.0%)
Headache
12 (1.8%)
14 (3.0%)
Fatigue
12 (1.8%)
13 (2.7%)
The following adverse events, reported by between 1% and 2% of patients receiving
UROXATRAL and occurring more frequently than with placebo, are listed alphabetically by
body system and by decreasing frequency within body system:
Body as a whole: pain
Gastrointestinal system: abdominal pain, dyspepsia, constipation, nausea
Reproductive system: impotence
Respiratory system: bronchitis, sinusitis, pharyngitis
Signs and Symptoms of Orthostasis in Clinical Studies: The adverse events related to
orthostasis that occurred in the double-blind phase 3 studies with alfuzosin 10 mg are
summarized in Table 5. Approximately 20% to 30% of patients in these studies were taking
antihypertensive medication.
Table 5 — Number (%) of Patients with Symptoms Possibly Associated with Orthostasis in 3-Month Placebo-Controlled Clinical Studies
Symptoms
Placebo
UROXATRAL
(n=678)
(n=473)
Dizziness
19 (2.8%)
27 (5.7%)
Hypotension or postural hypotension
0
2 (0.4%)
Syncope
0
1 (0.2%)
Multiple testing for blood pressure changes or orthostatic hypotension was conducted in the three
controlled studies at each scheduled clinic visit (Days 14, 28, 56, and 84). Patients with a
decrease in systolic blood pressure of >20 mm Hg after 2 minutes standing following being
supine were excluded from the three trials. These tests were considered positive for blood
pressure decrease if (1) supine systolic blood pressure was ≤90 mm Hg, with a decrease ≥20 mm
Hg versus baseline, and/or (2) supine diastolic blood pressure was ≤50 mm Hg, with a decrease
≥15 mm Hg versus baseline. The tests were considered positive for orthostatic hypotension if
there was a decrease in systolic blood pressure of ≥20 mm Hg upon standing from the supine
position during the orthostatic tests. According to these definitions, decreased systolic blood
pressure was observed in none of the 674 placebo patients and 1 (0.2%) of the 469
UROXATRAL patients. Decreased diastolic blood pressure was observed in 3 (0.4%) of the
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placebo patients and in 4 (0.9%) of the UROXATRAL patients. A positive orthostatic test was
seen in 52 (7.7%) of placebo patients and in 31 (6.6%) of the UROXATRAL patients.
No vital sign measurements were obtained following first dose administration in the phase 3
studies, except for a subset of patients in study 1 who had blood pressure measurements 12 to 16
hours after the first dose to assess the potential to produce orthostatic hypotension. None of
these 35 UROXATRAL treated patients showed a positive test for systolic, diastolic or
orthostatic blood pressure change.
Post-Marketing Adverse Event Reports:
The following adverse reactions have been identified during post approval use of UROXATRAL. Because these reactions are reported voluntarily from a population of uncertain
size, it is not always possible to reliably estimate their frequency.
General disorders: edema
Cardiac disorders: tachycardia, chest pain, angina pectoris in patients with pre-existing coronary
artery disease
Gastrointestinal disorders: diarrhea
Hepatobiliary disorders: hepatocellular and cholestatic liver injury (including cases with
jaundice leading to drug discontinuation)
Respiratory system disorders: rhinitis
Reproductive system disorders: priapism
Skin and subcutaneous tissue disorders: rash, pruritis, urticaria, angioedema
Vascular disorders: flushing
During cataract surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris
Syndrome (IFIS) has been reported in some patients on or previously treated with alpha-1
OVERDOSAGE Should overdose of UROXATRAL (alfuzosin HCl extended-release tablets) lead to hypotension,
support of the cardiovascular system is of first importance. Restoration of blood pressure and
normalization of heart rate may be accomplished by keeping the patient in the supine position. If
this measure is inadequate, then the administration of intravenous fluids should be considered. If
necessary, vasopressors should then be used, and the renal function should be monitored and
supported as needed. Alfuzosin is 82% to 90% proteinbound; therefore, dialysis may not be of
benefit.
DOSAGE AND ADMINISTRATION
The recommended dosage is one 10 mg UROXATRAL (alfuzosin HCl extended-release tablets)
tablet daily to be taken immediately after the same meal each day. The tablets should not be
chewed or crushed.
HOW SUPPLIED
UROXATRAL (alfuzosin HCl extended-release tablets) 10 mg is available as a round, three-
layer tablet: one white layer between two yellow layers, debossed with X10. UROXATRAL is
supplied as follows:
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Package NDC Number
Bottles of 30
0024-4200-30
Bottles of 100
0024-4200-10
Hospital Unit Dose (blister packs containing 10 cards of 10 tablets each)
0024-4200-20
Rx only.
Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled
Room Temperature].
Protect from light and moisture.
Keep UROXATRAL out of reach of children.
sanofi-aventis U.S. LLC
Bridgewater, NJ 08807
UROXATRAL
®
is a registered trademark of sanofi-aventis U.S. LLC.
Revised August 2008
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Patient Information
UROXATRAL® (Alfuzosin hydrochloride
extended-release tablets)
Read the Patient Information that comes with UROXATRAL before you start using it and each
time you get a refill. There may be new information. This leaflet does not take the place of
talking with your doctor about your condition or your treatment. You and your doctor should
talk about all your medicines, including UROXATRAL, now and at your regular checkups.
What is the most important information I should know about UROXATRAL?
• a sudden drop in blood pressure, especially when you start treatment. This may lead to
fainting, dizziness, or lightheadedness. Do not drive, operate machinery, or do any
dangerous activities until you know how UROXATRAL affects you. This is especially
important if you already have a problem with low blood pressure or take medicines to
treat high blood pressure. If you begin to feel dizzy or lightheaded, lie down with your
legs and feet up, and if your symptoms do not improve call your doctor.
What is UROXATRAL?
UROXATRAL is a prescription medicine that is called an “alpha-blocker”. UROXATRAL is
used in adult men to treat the symptoms of benign prostatic hyperplasia (BPH). UROXATRAL
may help to relax the muscles in the prostate and the bladder which may lessen the symptoms of
BPH and improve urine flow.
Before prescribing UROXATRAL, your doctor may examine your prostate gland and do a blood test called a prostate specific antigen (PSA) test to check for prostate cancer. Prostate cancer and
BPH can cause the same symptoms. Prostate cancer needs a different treatment.
UROXATRAL is not for use in women or children. Some medicines called “alpha-blockers” are used to treat high blood pressure. UROXATRAL
has not been studied for the treatment of high blood pressure.
Who should not take UROXATRAL?
Do not take UROXATRAL if you: • have liver problems
• are taking antifungal drugs like ketoconazole or HIV drugs called protease inhibitors
• are already taking an alpha-blocker for either high blood pressure or prostate problems
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• are a woman
• are a child under the age of 18
• are allergic to UROXATRAL. The active ingredient is alfuzosin hydrochloride. See the
end of this leaflet for a complete list of ingredients in UROXATRAL.
Before taking UROXATRAL, tell your doctor: • if you have liver problems
• if you have kidney problems
• if you or any family members have a rare heart condition known as congenital prolongation
of the QT interval.
• about all the medicines you take, including prescription and non-prescription medicines,
vitamins and herbal supplements. Some of your other medicines may affect the way you
respond or react to UROXATRAL.
• if you have had low blood pressure, especially after taking another medicine. Signs of low
blood pressure are fainting, dizziness, and lightheadedness.
• if you have a heart problem called angina (pain in your chest, jaw, or arm).
What you need to know while taking UROXATRAL (alfuzosin HCl) tablets
• If you have an eye surgery for cataract (clouding of the eye) planned, tell your
ophthalmologist that you are using UROXATRAL or have previously been treated with an
alpha-blocker.
How do I take UROXATRAL?
• Take UROXATRAL exactly as your doctor prescribes it.
• Take one UROXATRAL tablet after the same meal each day. UROXATRAL should be
taken just after eating food. Do not take it on an empty stomach.
• Swallow the UROXATRAL tablet whole. Do not crush, split, or chew UROXATRAL
tablets.
• If you take too much UROXATRAL call your local poison control center or emergency
room right away.
17
What are the possible side effects of UROXATRAL?
The most common side effects with UROXATRAL are:
• dizziness
• headache
• tiredness
Call your doctor if you get any side effect that bothers you.
These are not all the side effects of UROXATRAL. For more information ask your doctor or
pharmacist.
How do I store UROXATRAL? Store UROXATRAL between 59°F and 86°F (15°C and 30°C).
Protect from light and moisture.
Keep UROXATRAL and all medicines out of the reach of children.
General information about UROXATRAL:
Medicines are sometimes prescribed for conditions that are not mentioned in patient information
leaflets. Do not use UROXATRAL for a condition for which it was not prescribed. Do not give
UROXATRAL to other people, even if they have the same symptoms you have. It may harm
them.
This leaflet summarizes the most important information about UROXATRAL. If you would like
more information, talk with your doctor. You can ask your doctor or pharmacist for information
about UROXATRAL that is written for health professionals.
You may also visit our website at www.UROXATRAL.com or call 1-800-446-6267.
What are the ingredients of UROXATRAL? Active Ingredient: alfuzosin hydrochloride
Inactive Ingredients: colloidal silicon dioxide (NF), ethylcellulose (NF), hydrogenated castor
oil (NF), hydroxypropyl methylcellulose (USP), magnesium stearate (NF), mannitol (USP),
microcrystalline cellulose (NF), povidone (USP), and yellow ferric oxide (NF).
Rev. August 2008
18
Rx Only
UROXATRAL
®
is a registered trademark of sanofi-aventis U.S. LLC.
sanofi-aventis U.S. LLC
Bridgewater, NJ 08807
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2.3 |
Barrier Therapeutics Receives FDA Approval for Solage(R) Topical Solution Labeling ExpansionPosted on: Thursday, 3 May 2007, 12:00 CDT Barrier Therapeutics, Inc. (NASDAQ: BTRX), a pharmaceutical company that develops and markets dermatology products, today announced that the U.S. Food and Drug Administration (FDA) approved the company's application to add clinical data to the prescribing information for Solage(R) (mequinol 2%, tretinoin 0.01%) Topical Solution. The newly added information shows that Solage treatment for solar lentigines (age spots) is safe and effective in patients with darker skin types. The new prescribing information includes data from a Phase 4 post-approval study that demonstrated favorable results on the efficacy, safety and tolerability of Solage for the treatment of solar lentigines in patients with darker skin types. Study findings on the safety and tolerability of Solage in darker phototypes demonstrated a favorable benefit-to-risk ratio in the treatment of solar lentigines in African American, Asian and Latin/Hispanic patients. Over 80% of treated patients in this study achieved a significant response to therapy for facial and arm lesions. Additionally, the majority of subjects maintained clinical benefit during a 4-week post treatment period. These results are consistent with efficacy findings previously reported for Caucasian individuals. Ingredients and technical source: Pharmacology and use: Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage. Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.
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3.2 |
PSA Test Official Government Data Prostate-Specific Antigen (PSA) Test Karl Note: The original text includes a great many links which do not work on this page. I have left those links here, for your possible use. If you want to use all the links, simply go to the source page, link above. If you click on the links, other than the links to THE QUESTION LINKS, you will get non-useful results. The links to the question are working here. I've made them larger than the original and they are in purple color. Key Points
Selected ReferencesReturn To Top Of SegmentTop
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3.2 |
Official FDA Description of this Prostate Health Problem About Enlarged Prostate Enlarged prostate is a prevalent and progressive disease that affects 50 percent of men over 50 years of age and over 90 percent of men older than age 80.1 An enlarged prostate causes changes in urinary habits because of its location around the urethra. Over time, the prostate can continue to grow and urinary symptoms may worsen as the bladder loses the ability to empty itself. Left untreated, in severe cases, an enlarged prostate can lead to serious long-term problems including acute urinary retention (AUR) and the need for prostate-related surgery, and in rare cases even kidney or bladder damage. |
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3.3 |
Prostate Cancer Treatment ChoicesSourceTop
Congress has not been willing to change the basic economics of health care nor is it interested in changing how medicine is practiced in the United States. No matter how wrong, expensive, ineffective and dangerous Congress refuses to go to the roots of the crisis and make necessary changes. Fixing the fundamental problem with our medical system (soaring costs and mediocre results) requires that we look much deeper at the problem. If we don’t, the medical system will remain deeply troubled and will continue to hurt more people than it helps. Prostate cancer is a case in point. The official story about prostate cancer is that men can choose from at least five different courses of treatment. The simplest is known as watchful waiting, which means doing nothing unless later tests show the cancer is worsening. More aggressive options include removing the prostate gland or receiving one of several forms of radiation. The latest treatment called proton radiation therapy involves a proton accelerator that can be as big as a football field with the treatments costing 100,000. Unfortunately for the developers and investors very few people will be able to afford that option with a cataclysmic economic collapse in the making. Prostate cancer kills an estimated 35,000 men in the United States each year and attacks another 165,000. Most cases of prostate cancer do not occur until after men turn 50, but in recent years there has been a steady rise in the percentage of men in their 30s and 40s with both prostate problems and prostate cancer, primarily as a result of poor diet and increasing environmental pollution. One man in six will get prostate cancer during his lifetime The New York Times reported that, “Some doctors swear by one treatment, others by another. But no one really knows which is best. Rigorous research has been scant. Above all, no serious study has found that the high-technology treatments do better at keeping men healthy and alive. Most die of something else before prostate cancer becomes a problem.” “No therapy has been shown superior to another,” an analysis by the RAND Corporation found. Dr. Michael Rawlins, the chairman of a British medical research institute, said “We’re not sure how good any of these treatments are.” When asked, Dr. Daniella Perlroth of Stanford University, who has studied the data, what she would recommend to a family member, she paused. Then she said, “Watchful waiting.” 1) Watchful waiting costs a few thousand dollars in doctor visits and tests. Actually watching and waiting means doing nothing when there are plenty of wonderful and natural things one can do to improve PSA scores. (Note below that PSA scores do not offer the best guidance.) Top Use of I.M.R.T. rose tenfold from 2002 to 2006, according to RAND data. A new proton treatment center will open in July of 2009 in Oklahoma City, and others are being planned in Chicago, South Florida and elsewhere. The NY Times is very clear about the high costs of this procedure saying, “You may never see this bill, but you’re paying it. It has raised your health insurance premiums and left your employer with less money to give you a decent raise. The cost of prostate cancer care is one small reason that some companies have stopped offering health insurance. It is also one reason that medical costs are on a pace to make the federal government insolvent.” The cause of prostate cancer is unknown medical officials say A report published in the June, 2009 issue of A Cancer Journal for Clinicians shows that routine PSA blood tests often result in over diagnosis of prostate cancer, resulting in unnecessary treatments and psychosocial harm. Drs. Boyle and Brawley, of the International Prevention Research Institute, Lyon, France said, "The real impact and tragedy of prostate cancer screening is the doubling of the lifetime risk of a diagnosis of prostate cancer with little if any decrease in the risk of dying from this disease." 1 The PSA era is over in the United States," says Dr. Thomas Stamey, professor of urology and lead author of a study published in the Journal of Urology. "Our study raises a very serious question of whether a man should even use the PSA test for prostate cancer screening any more.2 From the time it first became standard to remove prostates in response to high PSA levels to the present - reveals that as a screen, the test now indicates nothing more than the size of the prostate gland.”3 According to the American Cancer Society, “There can be different reasons for an elevated PSA level, including prostate cancer, benign prostate enlargement, inflammation, infection, age, and race,” all factors that make PSA test results confusing, leading to potential for unnecessary treatment and suffering when tests are elevated. Complications of ill advised prostate cancer treatments include The Times did not mention the option of doing what makes sense while one watches and waits and it is hard to understand why. There is a list of natural nutritional agents that are helpful in treating prostate cancer including getting lots of sun exposure to drive up Vitamin D levels, which costs virtually nothing to do. One might need to purchase full spectrum sun lamps if one lives at extreme latitudes or if the sun is not shining enough but even that option is not costly. Iodine is also a key component because reduced iodine levels in the breasts, ovaries, thyroid and prostate glands predispose one to higher cancer risk. The great advantage of knowing the prime cause of a disease is
Prostate cancer is cancer that grows in prostate gland. Iodine as Chemo Agent Dr. David Derry said, “Lugol's solution is an iodine-in-water solution used by the medical profession for 200 years. One drop (6.5 mg per drop) of Lugol's daily in water, orange juice or milk will gradually eliminate the first phase of the cancer development namely fibrocystic disease of the breast so no new cancers can start. It also will kill abnormal cells floating around in the body at remote sites from the original cancer. Of course this approach appears to work for prostate cancer as prostate cancer is similar to breast cancer in many respects. Indeed, it likely will help with most cancers.” There are over 1 million prostate cancer tissue biopsy procedures performed annually in the U.S. Approximately 25% of these tissue biopsies are reported “positive”, indicating the presence of prostate cancer. The other 75% of prostate cancer tissue biopsies are reported as “negative”. Though it cost a bit more, Nascent Iodine is more palatable (less caustic) for oral usage and this is what I recommend for children. Lugol’s I reserve for transdermal application. At very high dosages we are talking about treatment costs of approximately 70 dollars a month at maximum doses. Meaning you can do iodine for more than a thousand months before you would spend what you would for having protons warped into your gland. This is the treatment to go for as is sodium bicarbonate, which we will talk about in depth below; we will see in the end which is the best way to go at any price or cost. A study conducted at University of Illinois has found an interesting Selenium also is highly indicated as a more than valuable supplement. A 1996 study by Dr. Larry Clark of the University of Arizona showed just how effective selenium can be in protecting against cancer. In the study of 1,300 older people, the occurrence of cancer among those who took 200 micrograms of selenium daily for about seven years was reduced by 42 percent compared to those given a placebo. Cancer deaths for those taking the selenium were cut almost in half, according to the study that was published in the Journal of the American Medical Association on December 25, 1996. In addition, the men who had taken selenium had 63 percent fewer prostate cancers, 58 percent fewer colorectal cancers, 46 percent fewer lung cancers and overall 37% fewer cancers. Selenium was found to reduce the risk of lung cancer to a greater degree than stopping smoking.5 There are now seven population studies in the past six years Also it makes more than perfect medical sense to increase intensely magnesium cellular (not serum) levels. Why because, “There is reasonable evidence to suggest that calcium may play an important role in the development of prostate cancer,” says Dr. Carmen Rodriguez, senior epidemiologist in the epidemiology and surveillance research department of the American Cancer Society (ACS). Rodriguez says that a 1998 Harvard School of Public Health study of 47,781 men found those consuming between 1,500 and 1,999 mg of calcium per day had about double the risk of being diagnosed with metastatic (cancer that has spread to other parts of the body) prostate cancer as those getting 500 mg per day or less. And those taking in 2,000 mg or more had over four times the risk of developing metastatic prostate cancer as those taking in less than 500 mg. Magnesium chloride or what is known as magnesium oil is the first item of importance on all my protocols. Please see Magnesium for Life site for more information. Calcium and magnesium are opposites in their effects It is no surprise to find another Harvard study in October 2001, which looked at dairy product intake among 20,885 men and found men consuming the most dairy products had about 32% higher risk of developing prostate cancer than those consuming the least High magnesium intake reverses calcification damages and inflammation when used intensely. High calcium levels interfere with Vitamin D and In this second half of this chapter we are going to focus on two other treatments that come at the exact other end of the spectrum from expensive proton therapy. First is sodium bicarbonate therapy, which is like a kind of natural chemotherapy that can be done easily and safely by anyone for less than five dollars and the other is prostate massage, which can be self administered for free or done by medical doctors. The two together with a full spectrum natural chemo protocol behind them would not only be highly cost effective for individuals and society but by all indications they would be effective and safe to do. Even if one wants to spend a fortune on more dangerous treatments both sodium bicarbonate and prostate massage should be required adjunct therapies since they can only improve results and reduce and buffer the toxicity and harm of aggressive chemical and radiation treatments. Actually both of these treatments and all the concentrated nutritional medicinals above offer us a nothing to lose and everything to gain treatment for prostate cancer. Hormone deprivation therapy causes tumours to shrink; With the latest advancements in our understanding of concentrated nutritional medicines we can now confidently present a protocol that makes doing nothing and waiting into an idiot’s option. We really don’t have to wait for innovative, improved and advanced treatment options for they exist already and the medical science is plentiful to backstop the use of the substances presented here. Sodium Bicarbonate Cancer Treatment Studies have shown how manipulation of tumour
Coloured scanning electron micrograph of two prostate cancer cells in the final stage of cell division. Photograph: VVG/Science photo library A healthy pancreas secretes sodium bicarbonate to neutralize stomach acid and create an optimal pH environment for pancreatic enzymes. Some of these enzymes circulate in the blood to destroy cancers that occur. Too much iron interferes with the ability of the pancreas to generate sodium bicarbonate and can lead to insulin resistance. Diabetes and cancer are linked because an unhealthy pancreas advances both diseases. pH of the blood is the most important factor to What is not generally understood is how basic to health pH and bicarbonate levels are and how easily we become acidic, which is an open invitation to have cancer visit ones life. These cancer cells look like yeast and fungi and you know what, many of them are and even mainstream oncology admits quite a bit of that. But whatever our definition and concept of cancer, it does not change the fact that cancer does not like what bicarbonate brings to the body. Most oncologists have no idea about how bicarbonate and CO2 are related and that bicarbonate deficiency leads to CO2 deficiencies in the blood. When our CO2 levels drop so do the levels of O2 and we do see cancer develop under low O2 and high acid conditions. Our body pH is very important because pH controls the speed of our In my book Sodium Bicarbonate, Rich Man’s Poor Man’s Cancer Treatment I write: Most of us are going to be surprised to find out that there is an oncologist in Rome Italy, Dr. Tullio Simoncini, destroying cancer tumours with sodium bicarbonate. Sodium bicarbonate is safe, extremely inexpensive and unstoppably effective when it comes to cancer tissues. It’s an irresistible chemical, cyanide to cancer cells for it hits the cancer cells with a shock wave of alkalinity, which allows much more oxygen into the cancer cells than they can tolerate. Cancer cells cannot survive in the presence of high levels of oxygen. Sodium bicarbonate is, for all intent and purposes, a killer of tumours. At a pH slightly above 7.4 cancer cells become dormant and at pH 8.5 cancer cells will die while healthy cells will live. Sodium bicarbonate possesses the property of absorbing heavy This has given rise to a variety of treatments based on increasing the alkalinity of the tissues such as vegetarian diet, the drinking of fresh fruit and vegetable juices, and dietary supplementation with alkaline minerals such as calcium, potassium, magnesium, cesium and rubidium. But nothing can compare to the instant alkalinizing and oxygenating power of sodium bicarbonate for safe and effective treatment of cancer. Cancer is actually a four-letter word — ACID, There are a multitude of methods to apply sodium bicarbonate and some of the best ways have hardly been tried by anyone. For prostate cancer Dr. Simoncini recommends that, “If there has been no surgical operation, it is possible to attempt firstly to treat the neoplasia through urethral catheters which allow the spreading of the saline solutions inside the prostatic lobes through the ducts. To this it is possible to associate periglandular infiltrations implementable transrectally by utilising very long needles of the type used for amniocentesis.” In my book, which is the first complete medical review of sodium bicarbonate in existence, I turn my back on Dr. Simoncini’s methods of bicarbonate application but do recognize him as a medical hero and genius. In the book was a testimony from a man whose prostate cancer had spread to his bones and after two weeks of high oral use he tested negative. Dr. Simoncini himself recognizes that for bone cancers his IV treatments are not effective and here we have a prostate patient resolving his bone cancer through oral means, which is safer and certainly hugely less expensive and widely more available. Though I believe in Simoncini’s work there are few doctors using his methods because of serious complications that would visit such practitioners by their local medical boards. But no matter, it is good news for humanity to have a universal way to treat cancer, which bicarbonate becomes if used orally and transdermally. Doctors all too often neglect to factor cost as we clearly see in orthodox oncology’s approach to prostate cancer. How can we compare spending $2.61 for a pound of sodium bicarbonate that we can eat and make into a liquid and apply all over our body with spending thousands of dollars for the same thing just so it can be administered through a needle? Most practitioners are new to natural transdermal medicine and how its power and safety can be brought to bear on glands like the prostate. Transdermal sodium bicarbonate treatments are even newer than Transdermal Magnesium Therapy, which is the title of my first book in print. Transdermal iodine therapy’s fame though goes all the way back to the American Civil War when iodine was used as a universal medicine. Prostate cancer demands we systemically take the pH up over eight and through oral means we can do this and have that pH register in all the tissues of the body. But we can also put a high concentration of bicarbonate in an enema and combat not only intestinal cancer and strong yeast overgrowth that way but we can have this treatment touch on the tissues intimate to the prostate area. Iodine can also be applied directly to the prostate tissue areas transdermally using a long swab or applying it liberally to genital areas and the perennial area though again oral administration is a must. Tullio Simoncini uses bicarbonate targeted more directly to the prostate thru the artery providing its blood supply.
Tumors are not distinguishable from the infections that inhabit them. Dr. Marijah McCain identified the primary cause of death in cancer patients to be not the cancer itself, but fungal overgrowth. Dr. Simoncini says, “At the moment, against fungi there is no useful remedy other than, in my opinion, sodium bicarbonate.” Bicarbonate is a chemo agent and in fact is used in oncology with its horrid list of chemo agents but it is used to buffer the effects of the dangerous chemo chemicals. Traditional chemo is just much too dangerous to do without sodium bicarbonate meaning the side effects would escalate beyond acceptable limits if not used. In fact, so dangerous and toxic are most chemo chemicals that many people would die on the spot without softening the blow with bicarbonate. We do not have to fear bicarbonate intake. And in fact, people who live in areas of the world with high amounts of bicarbonate in their drinking waters have a striking decreased mortality rate and a decreased prevalence of disease. Sodium bicarbonate, though often used as a medicine, is unlike pharmaceutical compounds. It is a natural non-toxic substance that does not require clinical trials for an assessment of toxicity. Spring waters contain bicarbonate ions which are coupled mainly with sodium, potassium, calcium or magnesium ions. A deficiency of bicarbonate ions in the body contributes to a range of diseases and medical conditions. The Prostrate and Sex When it comes to men, numerous researchers have shown that a high ejaculation frequency and sexual activity are linked to a lower risk of prostate cancer later in life. An epidemiological study of 30,000 men showed that men who ejaculated 13 to 20 times monthly presented a 14% lower risk of prostate cancer than men who ejaculated on average, between 4 and 7 times monthly during most of their adult life. Those ejaculating over 21 times a month presented a 33% decreased risk of developing prostate cancer than those on the baseline. Orgasm acts as a powerful pain-relief agent, and studies Michael Leitzman, a cancer researcher at the National Cancer Institute in Bethesda, Maryland and author of the above mentioned study, explains that there has been a suggested link with greater sexual activity and increased incidents of prostate cancer in previous scientific data because of the link with the male hormone testosterone and its effect on promoting cancer cell growth. But he says this theory has its shortcomings because testosterone levels alone do not predict prostate cancer risk and they do not appear to correlate with sexual desire as much as previously thought. Instead, researchers say ejaculation may protect the prostate through a variety of biological mechanisms that merit further research, such as: •Flushing out cancer-causing substances. Frequent ejaculation may help flush out retained chemical carcinogens in the prostate glands.
When men get older an enlarged prostate is a common problem. Fat and proteins can accumulate and enlarge the prostate gland to a degree where pain happens and urinating becomes a problem. A prostate massage is a good way to drain the prostate. Even if you do not have any problems with your prostate yet, it is recommended that you do a massage once a month to prevent problems. If you already have problems a daily massage may be needed to reduce pain and swelling but of course you should be taking medicinals like magnesium chloride. which will reduce the inflammation and clear out excess calcium from the area; iodine to deal with any infection and sodium bicarbonate which will flood the area with O2 and alkalinity. Although thought in terms of pleasure, prostate milking, another word or level of prostate massage, is performed for medical reasons. Inserted Note: (not in original): prostate massage can be accomplished as described here, generally a "manual massage" but there are numerous "devices" that allow this to be done with more privacy and probably more effectiveness. Here is an enlarged image of the manual method, showing the area inside the body where the massage takes place.
One source of the "device" that can be used is here:
Here is another source:
The source with this image also has this text:
“Part of the role of the prostate gland is to produce a clear fluid which makes up about thirty percent of male seminal fluid and, in cases of chronic prostatitis or benign prostatic hyperplasia, prostate milking can be used to reduce pressure in the prostate gland by removing excess fluid. Although it is possible to perform prostate milking externally by stimulating the prostate through the perineum this method is not always successful and it is more usual for prostate milking to be performed internally using a finger, prostate massager or a medical massager,” writes Donald Saunders, who gives clear instructions for how to do it oneself.9 (See reference for complete instructions.)
Doing prostate massages on oneself or having it done as a medical procedure or perhaps by a colonic specialist is not a joke. Prostate massage is part of the digital rectal examination (DRE) routinely given to men by urologists in order to look for nodules of prostate cancer and to obtain expressed prostatic secretions (EPS) for examination under microscope. Many instruct men to do this in order to keep the prostrate healthy. The massage does not only increase your health but can also improve your sex life and this is very important to men and their emotional health. During that initial visit, Dr. Zeitlin had to massage my gland twice to get the fluid out, and I think this accelerated my improvement. I felt much improved (say, 60% better) one week after the massage. I went back for a second massage one week later. It was painful, but he did drain more fluid...and today, one week later, I feel about 85% improved. After four months of agony, this is nothing short of miraculous to me. My bladder symptoms are all but gone. My perineal pain is all but gone.10 If you have an enlarged prostate then a prostate massage can clearly help. Massaging the prostate gland brings fresh blood and oxygen to the normally congested and suffocating prostate gland. Viruses, bacteria and fungus are just waiting for the right conditions in which to begin rapid multiplication. Rot is an underlying biological mechanism and infection is a natural process of biological decay, which congestion and blood stagnation encourages. Fresh healthy blood is healing to tissues and milking the prostate gland also all keeps all the sexual fluids (semen) fresh, clean, and moving out of the body. When fluids stagnate or blood and oxygen flows diminish disease thrives. In cases of chronic prostatitis (an inflammation of the prostate gland) or an enlarged prostate (benign prostatic hyperplasia, or BPH) prostate milking can be helpful in reducing pressure in the prostate gland by removing excess fluid. The prostate gland in many men suffers from blood congestion and stagnation when they are underactive sexually. When semen stagnates, it starts to decompose and becomes a breeding ground for bacteria and virus. The prostate needs a plentiful supply of fresh blood to nourish it with food and oxygen. And equally important, the prostate needs plenty of blood flow and regular semen release to keep clean, healthy and pain free. A man's prostate gland needs to be stimulated to discharge its load. If this is not done often enough, there would be a build-up of fluid secretions and this gland or sac that holds the fluid will be inflamed and infected. This stagnation of seminal fluid is one of the many causes of prostate cancer. One should do a massage at least once a month for about 10 to 20 minutes if one is concerned about the health of their prostate. It certainly would be a good thing for doctors to recommend to their male patients. There are things called prostate massagers, which you place on a chair, sit on it and use your own body weight to perform the massage and others that you simply insert. One-third of the men with initial prostate cancer tissue If you are suffering from as yet undiagnosed prostate cancer then cancerous cells could be broken up and distributed not only spreading cancer within the prostate gland but also causing it to metastasize and thus spread to other areas of the body. If one is diagnosed the prostate massage becomes an important part of ones treatment but it is essential to target the cancer with bicarbonate, iodine, magnesium chloride and selenium before one starts on ones massage routine. The idea is to completely change the condition not only inside and around the prostate gland but systemically as well so further cancer growth is not encouraged or allowed. Emotional Profiles are Important Some researchers have found that the average victim of breast or prostate cancer was unable to express such basic drives as anger, aggressiveness, or sexual impulses, suffered from an inner turmoil "covered over by a façade of pleasantness." In Psychosomatic Medicine, California's Dr. Eugene M. Blumberg and his colleagues report on patients with a wide variety of cancers: "We were impressed by the polite, apologetic, almost painful acquiescence of the patients with rapidly progressing disease, as contrasted with the more expressive and sometimes bizarre personalities of those who responded brilliantly to therapy with long remissions and long survival." Cancer is a message to us – it’s a loud scream from our Dr. Bernie Siegel said, “I have collected 57 extremely well documented so-called cancer miracles. A cancer miracle is when a person didn't die when they absolutely, positively were supposed to. At a certain particular moment in time they decided that the anger and the depression were probably not the best way to go, since they had such a little bit of time left, and so they went from that to being loving, caring, no longer angry, no longer depressed, and able to talk to the people they loved. These 57 people had the same pattern. They gave up, totally, their anger, and they gave up, totally, their depression, by specifically a decision to do so. And at that point the tumors started to shrink.” Conclusions One in three breast cancer patients today may be treated unnecessarily and thus incorrectly according to a 2009 study.11 We can infer, without such a study for prostate patients, that the story would be uniformly the same for them. Cancer sufferers en mass are being forced to pay with their lives for the incredible arrogance of oncologists and medical officials who refuse to open their eyes to see the medically sound solutions that are already out there. Why should our loved ones suffer for their ignorance? There are many ways to treat cancer and new ideas are constantly being presented and then ignored. A study published in the European medical journal Anticancer Research demonstrates a substance used as a cough suppressant for over fifty years may be useful in treating advanced prostate cancer. Researchers from the Prostate Cancer Research and Educational Foundation, the MedInsight Research Institute, and the University of California in San Diego found that noscapine, a non-addictive derivative of opium, reduced tumor growth in mice by 60%. What's more, it halted the spread of tumors by 65% and caused no harmful side effects. Medical marijuana, especially when taken in the form of oil, is also known to arrest cancer while it simultaneous deals with the mental emotional makeup of the cancer sufferer as it reduces pain and emotional upset. Part of any successful cancer treatment includes Spices add flavor to food but also may have cancer-fighting properties. India has one of the lowest cancer rates in the world, and the people there typically eat a diet containing a wide variety of spices. There is some limited evidence that capsaicin, the component of chile peppers that makes them hot, has some anti-cancerous properties. Both curry and cumin contain turmeric, which has been found to have anti-carcinogenic properties in cell cultures.12 In studies involving mice, curcumin has demonstrated anti-carcinogenic activity in a variety of cancers.13 A compound in aged garlic significantly inhibited the growth of human prostate cancer cells in vitro.14 There is so much we can do for ourselves but there the medical system insists that we either do nothing or surrender to the scalpel or dangerous radiation machines. One should seriously consider changing one’s diet and pay close attention to the quality of ones water and how much water one drinks. Using super foods like spirulina or wheat grass juice are wonderful therapies as are colonics or natural enemas, getting lots of body work and even acupuncture has clearly demonstrated its usefulness for prostate patients. Literally there is no end to the things one can do to help oneself including taking hot therapeutic baths loaded with magnesium, bicarbonate and even sodium thiosulfate. It is shocking how many people die from cancer even after governments have thrown the kitchen sink at it. After hundreds of billions spent on research people are still dropping dead at close to the same rates as years past but no one thinks that the medical establishment is at fault. It literally cost me nothing to put this information and essay together yet medical officials and organizations don’t want the public to have easy access to these kinds of treatments. Sodium bicarbonate is a nothing-to-lose- Every man should have all this information in his hands and every woman who has a man she loves should have it as well. But the vast majority will not receive it because the channels of mass communication are blocked and controlled by the elite who really do mean us harm. They want to hurt us and our loved ones but they will never admit that. They enjoy having us in their hands because they profit from it. The profit motive does not belong in the field of medicine and certainly not in oncology were it’s a matter of life and a promised miserable death. Capitalism certainly has shown its ugliest face in the vast field of medicine, which sucks up a huge percentage of GNP, and even so does a miserable job. With the guidance of an enlightened healthcare practitioner
Mark Sircus Ac., OMD _________________________________________________________ 1 www.examiner.com/x-14041-Charlotte-Health-and-Happiness-Examiner~y2009m6d29-Prostate-cancer-test-value-not-proven-says-report and www.cancer.gov/cancertopics/factsheet/detection/PSA 3 through the years, Stamey has come to believe that the PSA test is actually not a useful predictor of the amount or severity of prostate cancer. He said elevated levels of that protein, prostate specific antigen, a protein normally produced by the prostate gland. actually reflect a condition called benign prostatic hyperplasia, a harmless increase in prostate size. 4 Dr. Q.Y. Lu and colleagues from the University of California at Los Angeles found that, "These avocados were found to contain the highest content of lutein among commonly eaten fruits as well as measurable amounts of related carotenoids (zeaxanthin, alpha-carotene, and beta-carotene). Lutein accounted for 70% of the measured carotenoids, and the avocado also contained significant quantities of vitamin E. An acetone extract of avocado containing these carotenoids and tocopherols was shown to inhibit the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro. Incubation of PC-3 cells with the avocado extract led to G2/M cell cycle arrest accompanied by an increase in p27 protein expression." 5 Clark LC. The epidemiology of selenium and cancer. Fed Proc 1985; 44:2584-2590. 6 Accu-Cell Nutrition; Calcium and Magnesium www.acu-cell.com/acn.html 7 www.topnews.in/healthcare/content/-2675why-prostate-cancer-patients-become-resistant-hormone-deprivation-therapy 8 Enhancement of chemotherapy by manipulation of tumour pH. Raghunand N, He X, van Sluis R, Mahoney B, Baggett B, Taylor CW, Paine-Murrieta G, Roe D, Bhujwalla ZM, Gillies RJ. Arizona Cancer Center. It is very important to milk the prostate gland from the top to the bottom, squeezing it gently all the way down. Never use undue force and always perform prostate milking as gently as possible and with just sufficient force to stimulate the prostate gland. If you think in terms of the force used when gently massaging a tired eyeball this is about the right pressure. There are several potentially serious consequences to over-vigorous milking: If you are suffering from prostatic calculi (small stones within the prostate gland) these can act rather like scouring grit and tear the delicate membranes of the gland. The rectal lining in the area of the prostate gland is very thin and can easily be perforated. The best instrument for milking the prostate gland is an Aneros prostate massage device. It is designed to give a perfect prostate massage and prostate milking. The difference when milking the prostate gland (rather than massaging the prostate) is that you will push the Aneros all the way in, apply pressure to your prostate, and then manually run the Aneros down over the full length of the gland. During a prostate massage, you simply squeeze the Aneros with your anal contractions. If you do the massage by hand, simple use your fingers (your middle finger). However, your fingers (middle finger) may be too short to reach the prostate gland, so try it out and use the massager otherwise. Because of the angle it may not be so easy. Risk is low that you hurt yourself. Try to find the middle of your prostate and start the massage. You can find a ridge or indentation there. You can massage the prostate until fluid leaks out. This is also called milking the prostate. If possible urinate after the drainage to wash it away. Usually you can feel the fluid move during the massage. This is a sign that you are doing it right. Your prostate can be swollen quite a lot so finding it should be easy. Slow continues pressure is the best. If you really have a very swollen prostate with a lot of pain then you could do a massage and drainage daily. ezinearticles.com/?The-Ins-And-Outs-Of-Prostate-Milking-Or-Prostate-Massage&id=640873 1. Before attempting prostate milking pay a visit to the bathroom to ensure that both your bladder and bowel are emptied. 2. Ensure that your fingernails are trimmed short and that your hands and the area around your anus are washed thoroughly. Top 11 Karsten Jorgensen and Peter Gotzsche of the Nordic Cochrane Centre in Copenhagen analyzed breast cancer trends at least seven years before and after government-run screening programs for breast cancer started in parts of Australia, Britain, Canada, Norway and Sweden. The research was published in July of 2009 in the BMJ, formerly known as the British Medical Journal. 12 Rao CV, et al. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 1995; 55: 259-66. 13 Huang MT, Newmark HL, Frenkel K. Inhibitory effects of curcumin on tumorigenesis Legal Notice: The Author specifically invokes the First Amendment rights of freedom of speech and of the press without prejudice. The information written is published for informational purposes only under the rights guaranteed by the First Amendment of the Constitution for the United States of America, and should not in any way be used as a substitute for the advice of a physician or other licensed health care practitioner. The statements contained herein have not been evaluated by the FDA. The products discussed herein are not intended to diagnose, cure, prevent or treat any disease. Images, text and logic are copyright protected. ALL rights are explicitly reserved without prejudice, and no part of this website may be reproducedTop |
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3.4 |
My About-Face on the PSA Test Why every man should have this prostate test done today! Karl Note: This small part of this article? I found, but could not download the remainder -- this is left here incomplete. Source This report may come as a real shock to you. I’m officially doing an about face on the PSA test.
That’s all changed. And you need to know why. I’ve recently discovered that the PSA test could save your life. But not in the way you may think. In 2004, American Cancer Society statistics show that 32,000 men died from prostate cancer in the U.S. Doctors diagnosed over 232,000 new cases in the same year. In fact, prostate cancer is the most common malignancy to affect men. It’s the second leading cause of cancer death in men after lung cancer. And the incidence is escalating |
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3.5 |
FAKE Source of Data About Prostate Cancer
Karl Note: The reason I label this data as "fake" is that I discovered an amazing thing about the reduction in value of the Google Search Service, and wrote about that HERE. Nontheless, I've included this "fake information" here since that may be all that can be found -- no longer can you expect to find any "personal opinion" with a name attached to that opinion. Click on the "source" link above to explore just how deceptive this web site, and therefore, the data from it are. If prostate cancer is caught before reaching the end stage, then it is often treated very successfully. Treatment has been getting higher and higher success rates within the last twenty years, although it is still not known what causes the cancer and how to prevent it. When a cancer reaches its end stage the patient may start to show signs such as weight loss, tiredness and pains in different places. In the case of prostate cancer, this is especially true in the lower back and hips.
Karl Note: This below is the type of "theety-weety" pablum that you can find with most web search results -- JUNK. If you find something different, it will ususally be selling some snake oil. Web sites that offere apparently valuable information often won't let you see it without providing at least your eMail address and most often your complete name and address -- before you get the goody. Beware such places, they sell your name to hundreds so you can expect to get lots of spam junk. All content at ProstateCancerFAQ.org is for informational purposes only. We do not give medical advice, nor do we provide medical or diagnostic services. We strongly emphasize that the content provided on this website, by the admin, or any of its authors, is not to be substituted for professional medical advice, diagnosis or treatment. Always consult with your doctor or other qualified healthcare provider. Never disregard professional medical advice or delay in seeking medical treatment because of something you have read, seen or heard on ProstateCancerFAQ.org The site is provided to you on an "as is, with all faults" basis. |
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3.6 |
Suggestion From Karl's Close Friend Dr. MSR Ayyangar, Mumbai, India Karl Note: Dr. MSR Ayyangar is an Ayurvedic Physician, a Doctor of Homeopathy in regular practice in Mumbai, India, knows Karl Loren and his family personally from visits to the USA, staying at the residence of Karl in 2008 and earlier. Dr. Ayyangar is a man of great credentials, worldwide, including the following he sent along with his suggested protocol: Dr. Ayyangar: I just returned from a lecture tour (15th to 20th) of South India having delivered lectures on "Green Chemistry" sponsored by different departments of Government of India connected with environment - and - spiritual philosophies in Management in Business schools. The organizers insisted on my being the "Chief Guest" during the seminar ... though I insisted that I have no knowledge on this field of chemistry. But in the final reckoning ... only I was quoted by all the News Papers with my Photograph being prominent & TV Channels extensively showing their interviews with me. Selenium (Selenomethionine) + Pycnogenol .... is a very good choice for you. Normally Prostate Cancer is benign, self limiting and does not quickly tend to become malignant or spread and become metastatic. There are now laparoscopic methods available to remove Prostate Gland with minimal collateral trauma to the surrounding tissue. Click Here for Photo Slide Show of Dr. Ayyangar and his wife, visiting with Karl Loren and his family, including Mr. Clifford Woods.
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3.8 |
Scientific evidence shows vitamin D may go beyond its traditionally known role in maintaining bone integrity, according to new research presented at the Institute of Food Technologists Annual Meeting and Food Expo® earlier this month. It may play a role in preventing autoimmune dis-eases or over-acid tissue conditions such as multiple sclerosis and rheumatoid arthritis, some types of cancerous conditions such as breast, ovarian, colorectal and prostate. Advancing technologies to add vitamin D to natural foods create offerings that provide excellent sources of both vitamin D and calcium which can help consumers achieve dietary adequacy of these largely under-consumed nutrients. "Low vitamin D status is linked to a number of different conditions," said James C. Fleet, Ph.D. professor in the department of foods and nutrition at Purdue University. "These include certain cancers, muscle weakness and types I and II diabetes--possibly even schizophrenia and multiple sclerosis." Although it remains controversial, 30 nanograms/milliliter (ng/mL) of vitamin D is associated with fewer fractures and falls, according to Karen Hansen, assistant professor of medicine within the rheumatology section at the University of Wisconsin. "Vitamin D deficiency causes osteoporosis by triggering decreased calcium absorption, secondary hyperparathyroidism, increased bone resorption and decreased bone mineral density." Study variables and inconsistencies make further studies necessary. Currently, 700 to 800 International Units (IU) of vitamin D a day seems most effective. According to Dr. Robert O. Young, Director of Research at the pH Miracle Living center, "recommendations for an "adequate intake" of vitamin D should be at 50,000 IU's for maintanance and 100,000 IU's in any acute or chronic condition, including diabetes, MS, heart dis-ease and cancerous conditions."
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3.81 |
Vitamin D Helps To Prevent Cancerous Breasts and Tumor Formation By Dr. Young Source: Private eMail to Karl A connection between vitamin D level and the risk While previous studies had concentrated chiefly The result of the study involving 1,394 cancerous Women with a very low blood level of 25(OH)D have In addition, the investigators focused on the Besides its cancerous-preventing influence with According to Dr. Robert O. Young, Director of Research at the pH Miracle Living center, "recommendations for an "adequate intake" of vitamin D should be at 50,000 IU's for maintenance and 100,000 IU's in any acute or chronic condition, including diabetes, MS, heart dis-ease and cancerous conditions." |
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3.9 |
ABNORMAL PSA LEVEL/GLEASON GRADE: What is an abnormal PSA level and what are grade levels for prostate cancer? Answer: Some doctors would say the PSA level is normal if it's below 4 ng/ml and above normal if it's above 4 ng/ml. I believe that the cutoff of 4 is too high and we have used 2.5 as our cut off in our PSA screening study since 1995. We have proven that if the PSA is between 2.5 and 4, there is a 22 percent chance that the man will have prostate cancer. We routinely recommend a biopsy if the PSA is above 2.5 and if the free PSA test confirms the advisability of performing a biopsy. Even men with PSA levels lower than 2.5 might have prostate cancer. In our studies, the median PSA level in men without known prostate cancer was less than 1 in men in their 40s and 50s and less than 1.5 in men over the age of 60. It the PSA level is higher than the median for the age group, the risk of prostate cancer is higher. So, if the PSA level is above the median and especially if it is rising, a biopsy should be considered. Prostate cancers when looked at under the microscope can look like almost normal prostate tissue or they can look very wild and disorganized. They are graded on a scale called the Gleason grade of between 2 and 10 where 2 is the best, i.e., a low grade, slow growing prostate cancer, and a 10 would be the worst, i.e., a rapidly progressing, very aggressive prostate cancer. It turns out that grade level statistics for prostate cancer fall into a bell shaped curve. Only about 10 percent of tumors are grade 2, 3 and 4 and only about 10 percent of tumors are 8, 9 and 10 with the vast majority being Gleason grades 5, 6 and 7. Gleason grades 8-10 are considered highly aggressive, Gleason 7 is considered moderately highly aggressive (4+3 is considered to be more aggressive than 3+4), Gleason 3+3 is considered mildly aggressive, and Gleason 2-4 is considered so non-aggressive that immediate treatment might not be needed in men over the age of 70. VIAGRA AND PSA RESULTS: Q: Does taking Viagra the night before a PSA test affect the results? A week before?
Answer:Our studies show that prostatic biopsies can easily miss prostate cancers. In our recent analysis of more than 2500 men who underwent one or more prostate biopsies, of those who had cancer detected, only 77% had the cancer discovered on the first biopsy. Of the rest, 91% were discovered on the first or second biopsy, 97% on the first three biopsies, and 99% on the first 4 biopsies. Some men required 6 biopsy sessions to detect the cancer. So, with each biopsy session there is increased confidence that the high PSA might not be due to cancer. However, there is a current trend among urologists to obtain more biopsy cores during each biopsy session and to perform the biopsies under local or general anesthesia so that more biopsy samples can be obtained without undue discomfort. It is also important to ensure that the biopsies are directed to the zones of the prostate where most of the cancers are found. In some men the cancer may be located in the central region of the prostate gland where biopsies are not usually directed. Sometimes these cancers can be best detected on transurethral recection biopsies, obtained under anesthesia through a scope that is passed into the central part of the prostate gland. These biopsies are sometimes called “saturation biopsies.” Some men with high PSA values do not have prostate cancer. Other options are to try a long course of antibiotics such as Cipro 500 mg twice a day to see if it brings the PSA down. Other criteria to consider is the PSA density (PSA divided by prostate volume). If it is higher than 0.10, it is worrisome for prostate cancer. Also, measuring the percentage of free PSA (free PSA/total PSA x 100). If it is lower than 25%, it is of concern - and the lower, the more concerning. Certainly, annual biopsies are not unreasonable, especially if the PSA or other parameters continue to suggest a higher risk for prostate cancer.
Answer:The PSA increase may be due to inflammation in the prostate. So, the first step is to take a 10 to 14 day course of antibiotics (such as Cipro 500 mg twice a day). Of course, if the PSA does not come back down, a biopsy of the prostate should be considered.
Answer: When the total PSA is between 4 and 10 and the percentage of free PSA is less than 10, there is about a 58% chance that biopsies will show cancer. This means that there is a 42% chance that the biopsies will not show cancer. I would advise that you monitor the total PSA level and the free PSA level, and if the total PSA level rises, consider further biopsies. It is possible that with a large prostate gland, there could be areas of cancer that were missed by the first two sets of biopsies. If you want to be as pro-active as possible, you might want to consider repeating the biopsies again in one year. It is well established that BCG therapy for bladder cancer can induce chronic inflammation in the prostate gland that can result in a long-term elevation of the PSA level.
Answer:There is still much to be learned about free PSA. We now know that there are several forms of it. One form is low in cancer and high with benign enlargement of the prostate. However, another form is high in cancer. In general, a low percentage of free PSA is worrisome for cancer – but not always. There are some men who have a low free PSA and do not have cancer. We don't know all of the explanations at this time.
Answer: There are several possible explanations. Part of the high PSA could be due to benign prostatic enlargement or inflammation in the prostate. The cancer may be contributing a relatively small proportion of the PSA. Another possibility is that the biopsies may have failed to detect other regions of cancer within the prostate due to simple spatial sampling errors.
Answer: Yes. A PSA count of 10 is high at any age. It indicates that there is either benign enlargement of the prostate, inflammation in the prostate, prostate cancer - or a combination of the above. It would be prudent to be evaluated by a urologist.
Answer: The answer to all three quesitions is yes. Usually, ejaculation or a prostate exam has only a slight effect on the PSA level that lasts for 24 to48 hours only. The PSA might increase a point or two. With infection, very high PSA levels can occur (even up to 21 or higher) and in some cases it takes a long time for the PSA levels to return to baseline. In about 25% of cases, antibiotic therapy is effective; however, some men have to wait for their body’s defense mechanisms to clear the infection.
Answer: A rising PSA in a patient on Proscar is worrisome for prostate cancer. There are treatments to slow the progression of the cancer. The size limits some treatments, but not radiation or stronger hormonal therapy. If the PSA increase is due only to prostate cancer, it indicates a rapidly growing tumor; however, the increase could also be due, at least in part, to inflammation in the prostate (see other Q&A s on this topic). It never hurts to get another opinion from another urologist, medical oncologist or radiation oncologist.
Answer: The only medicines that affect PSA levels are hormones. Medicines that lower male hormones can decrease PSA levels. The only way a cough or cold medication could affect the PSA level would be if it caused urinary retention. Urinary retention can result in a dramatic increase in the PSA levels.
Answer: I do not believe so. There are probably other causes (benign enlargement of the prostate, inflammation in the prostate, prostate cancer, or combinations of the above). See other questions on the website. Ejaculation usually causes only low-level transient elevations of the PSA level.
Answer: Pro-PSA is a "new" marker. Preliminary studies indicate that it may be a better marker than free or complexed PSA, but a Pro-PSA test is not available at this time. The test and its results are still in the research stage. Some papers are published on clinical studies using Pro-PSA, and they can be found on the internet in PubMed, a service of the National Library of Medicine, www.pubmed.com. The Fall 2003 issue of Quest had an article on Pro-PSA, “Pro-PSA: Possibly a Better Marker for Prostate Cancer.”
Answer: Yes. In recent years, it is very uncommon for pathologists to score prostate cancer in the low end of the Gleason scoring range (less than Gleason sums of 5). It is always a good idea to have slides reviewed, and especially so in this case.
Answer: In my opinion, he almost certainly has advanced prostate cancer. If it does cause symptoms, it is very likely that he could be successfully treated with hormonal therapy. If he does not wish to have a biopsy, he should be monitored closely by an experienced urologist who would be prepared to intervene appropriately.
Answer: In my opinion, nothing but to continue to watch the PSA carefully and to be willing to have more biopsies if the PSA rises further. Biopsies in the anterior and the central regions of the prostate are especially important in cases such as yours.
Answer: The adrenal glands normally produce male hormones in relatively small quantities that can affect PSA levels. In fact, some treatments for advanced prostate cancer, such as keotconazole probably lower PSA levels by eliminating the production of male hormones by the adrenal glands.
Answer: I is more likely to be prostatitis because of your young age, but it could be cancer - especially if you have a family history of early age at onset prostate cancer. If the PSA does not decrease below 2.5 with the antibiotics, I would recommend that you have a biopsy.
Answer: Many men have a high PSA because of benign enlargement and/or inflammation and do not have cancer. The odds are that you are one of these men. It is important to stay under the care of a urologist and make sure you go in for scheduled tests and check-ups. These may include repeated biopsy sessions, especially if the PSA continues to rise, as biopsies are only small samples of the prostate gland, and it is not infrequent that initial biopsies miss the cancer.
Answer: It could if your testosterone level was low to start with (as it presumably was) and therefore was masking your true PSA level. If the PSA is high, you should consider a prostate biopsy
Answer: In my opinion, a PSA of 2.9 is too high. I would continue to monitor the PSA quarterly, and, if it does not continue to decrease, would recommend a biopsy.
Answer: No.
Answer: Not to my knowledge. Neither gout or the medications used to treat it affect PSA levels. The most common cause of a fluctuating PSA level is inflammation in the prostate gland, but it is possible also to have benign enlargement and cancer. I would advise another course of antibiotics, and if the PSA does not return to baseline, I would advise a prostate biopsy. Q: FLUCTUATING PSA RESULTS: What would make a man's PSA go from 4.8 to 9.l then back to 5.4 and back to up to l0.9. His digital rectal exam was normal. Answer: Inflammation in the prostate, also called prostatitis. However, remember that a PSA of 4.8 and 5.4 is high and it is possible to have both prostatitis and prostate cancer. If the PSA does not decrease to below 2.5, I would recommend that you have a prostate biopsy. Please see other Q&As on my website referring to fluctuating PSA levels.
Answer: I would recommend asking your urologist to culture your urine and try a 4 to 6 week course of antibiotics, such as Cipro 500 mg twice a day, to see if that has a beneficial effect on your symptoms and PSA level. Your urologist might want to check your urine for abnormal cells with a cytology test and might want to perform cystoscopy to ensure that everything looks alright on the inside. It might be necessary to repeat the biopsy procedure in the future.
Answer: A high PSA does not always mean cancer. It can be caused by an enlarged prostate gland, inflammation in the prostate gland, or other benign conditions. However, the higher the PSA, the greater the likelihood that prostate cancer is present.
Answer: It can raise PSA levels if the PSA levels were suppressed because of the low testosterone level, which often is the case when the testosterone level is low enough to warrant treatment. However, if the testosterone levels are not abnormally low, giving additional testosterone might not increase the PSA levels.
Answer: Pro-PSA is not yet available for clinical use. No guidelines have been established at this time.
Answer: You could start at once and get a baseline PSA and digital rectal examination, and, in my opinion, it would not hurt to repeat it annually. In any case, I would not recommend waiting until after age 40.
Answer: At least annually, and, in my opinion, every 6 months would not be too often. A 45 year old’s PSA should be less than 1.0 ng/ml at age 45. If it is higher, I would advise a course of antibiotics and if the PSA did not decrease to lower than 1, I would advise considering a biopsy.
Answer: The median PSA value for men in their 40s is about 0.6 ng/ml. If the PSA is higher, there is a higher risk of being diagnosed with prostate cancer. I would advise you to try a course of antibiotics and if the PSA did not decrease to lower than 1, I would advise you to consider having a biopsy. If you do not have a biopsy, you should follow your PSA very closely.
Answer: Your PSA is a little bit higher than that of the usual 52 year-old man (median PSA 0.6-0.9). With your family history, I would advise you to continue to follow it carefully and if it trends upward at all, I would recommend that you consider having a biopsy.
Answer: In my opinion, yes. I would advise you to have a biopsy.
Answer: It could. We now know that "free" PSA is made up of several components: BPSA and IPSA that are increased with benign prostatic enlargement (BPH) and proPSA that is increased with cancer. So, if the prostate shrinks because of treatment of BPH, the free PSA level could decrease.
Answer: It is hard to say, but certainly higher, and high enough to recommend a biopsy.
Answer: Although your tumor features and PSA velocity are favorable, I would not recommend watchful waiting because of your young age. Your prostate cancer will have a long time to progress, if you are otherwise healthy, and the earlier you have it treated, the better, in my opinion.
Answer: The range is from 0 to thousands. In men with a perfectly healthy prostate gland (i.e., no benign enlargement, no inflammation, no cancer) the PSA should be less than 1. Any of these conditions can raise the PSA level. However, there is a direct association between the PSA level and the risk of cancer. It is about 10% to 15% if the PSA is less than 2.5; about 25% if the PSA is 2.6 to 4; about 35% to 40% if the PSA is 4-10; and more than 50% if the PSA is higher than 10. See the Quest article of August 2004 for more recent information on other PSA measures such as PSA velocity, PSA density, Pprcent free or complexed PSA, etc.
Answer: They have no effect on the PSA level. Only urinary tract and prostate infections affect the PSA.
Answer: If the suspicious cells were high-grade PIN (prostatic intraepithelia neoplasia) or ASAP (atypical small acinar proliferation), and the percent free PSA is decreasing to 6%, I would be concerned. However, it is reassuring that his total PSA has not increased for the past two years. Perhaps, the safest course would be to repeat the biopsy procedure. If you do not wish to do this, I would recommend that the PSA levels be measured every 3 to 6 months.
Answer: No. In fact, emerging evidence suggests that medications for cholesterol (statins) might lower the risk for prostate cancer and might decrease the aggressiveness of prostate cancer.
Answer: No, there isn’t.
Answer: Men with a family history of prostate cancer are often biopsied at a younger age– due to an elevated PSA – than men without a family history of prostate cancer.
Answer: There is truth to the fact that not everyone with a high PSA value has prostate cancer, especially if the PSA decreases spontaneously or in response to antibiotic treatment. |
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4.1 |
Karl Loren's Treatment Protocol Ph Flush™ Formula Created by Karl Loren, four capsules per day, spread evenly, provide a total of: Germanium -- Pure Powder 2 grams per day Taheebo Life Tea -- pure powder, equivalent of 40 capsules per day Selenium -- 400 mcg per day Pycnogenol -- Form and amount as created by Clifford Woods Alkaline Water and Regular pH testing to ensure drinking of 8.0 water and body fluids maintaining steady alkaline state. |
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9.9 |
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Karl Note Inserted: It appears from the adverse side effects listed below that this drug company may be withholding adverse information, and could be sued. I found them on the web at a bit less than $3.00 per pill..
The majority of men have not even heard of prostate stimulation or have any concept of what it is. However, for those who have and had the pleasure to experience prostate stimulation, you are not likely to forget it!
Another source of useful data
STRESS AND PSA: Is there a known relation between personal stress and PSA results?
| Date/Time | Weight | Fat % | Muscle | RestMetab | BMI | VisFat | Blood Pressure |
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07.17.09:10:30 AM |
130/xxx Pulse 74 | ||||||
| 07.19.09:1:25 PM | 252.6 | 27.3 | 31.3 | 2086 | 41.1 | 29 | 159.88L87 |
| 07.20.09: 8:00 AM | 252.0 | 29.4 | 30.4 | 2885 | 41.0 | 29 | 178/92 Pulse 75 3:18 AM |
| 07.21.09 AM | 253.2 | 30.1 | 30.0 | 2093 | 41.2 | 29 | 190/109 Pulse: 67 4:08 /AM (very cold roon) |
| 07.24.09 AM | 253.4 | 30.1 | 2093 | 41.1 | 29 | 179/84 Pulse 91 /AM |
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eMail Exchanges With Subscribers
| Date/Reference | Click on Message Reference for the message |
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References |
Jim, started on 07.20.09
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| Jim: Started on 07.20.09 |
Message_Text: Dear Karl, I am a 71 year old 205 # white male with a 130 gram prostate. My psa has been from 4.5 to as high as 23. for the last couple of years it has been 5 to 7 while taking uroxatrol and avodart. Had a biopsy 1998 and mris 2 years ago both negative. I would very much like to get off the meds but am afraid of not being able to urinate when on a camp or hunt trip as well as getting up 5 to 8 times a night and not get a good nights sleep. Any thoughts or suggestions greatly appreciated. Thank you kindly. Jim Response from Karl on 07.20.09 Dear Jim, Your last name is familiar. Have we had contact in the past? It happens that I have a considerable interest in PSA and prostate since, less than a week ago I got my first "high" PSA score -- it was 15. I am 78, used to hike a great deal when I was a youngster like you. I immediately started a new web page, this one, on which I am publishing my research and personal treatment protocol. I weigh more than you -- I need a sleep Apnea mask to get a good night's sleep -- also greatly reduces the need to urinate during the night. I usually only get up once, maybe 4 AM, and often just stay up then to do some work on one of my web sites. I also get in my pool exercise and sauna every day, usually 7 days per week. I often do this -- publish some personal health problem BEFORE I have solved it, then work on the solution, all the while publishing my results on a daily basis. I also, generally, publicize the web page I use, and encourage you to subscribe to my Premium Edition of the Dark Times Digest (can be done here) and exchange messages with me, personally. I will not publish any of your personal information unless you authorize it, but I will publish our exchange of messages as long as they seem of interest to my viewing public. However, if you are willing I would love to put your picture here and any other personal information you are willing to share. One of my favorite photos is here. As you can see I'm a Kung Fu student -- started when I was 74. I have an earned Orange Belt and an honorary Black Belt from my Kung Fu School' where I am the school webmaster and photographer. I have published thousands of my photos on that site.
The other image is of me and my wife, practicing Kung Fu Stick Fighting right in front of the small pool I use for daily exercise. That's my dog Scotty on the left in the photo. Here is me in the pool doing Kung Fu punches:
So, this web page is my first suggestion that you look over -- particularly the two very personal "notes" I've written about my own PSA and prostate cancer situation: Note1 and Note 2. You can also browse through any or none or all of the pages on that Web Site -- this is where I publish my Dark Times Digests. Let me know what you think of all this? Thanks, Karl Loren.
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| Mike: 07.21.09 |
Hi Karl, I'm new to your site but in the last 24 hrs I've read an awful lot and I've actually asked questions regarding some personal issues I'm dealing with and received a polite email back from an assistant. The information did not teach me anything new about hypothyroidism but it would be fair to say I have really educated myself on the subject. Unfortunately, it was the day after my wife had a CT scan that the red flags started coming up all over the place about the dangers in these scans. Turns out 65% of people who have this particular scan perform fall victim to thyroid cancer within 10 years. I'm off topic a little here, the point of this letter relates to some of the advice you were giving young parents who have autistic children. You seems certain that pre natal issues play a large role, perhaps you are not aware as government in Canada and the US are purposefully delaying and appealing court decisions on the matter but I can tell you with confidence that the MMR vaccine (measles, mumps and rubella) is the likely cause of autism. You are right about mercury playing the role which makes this whole topic quite sickening. Why would vaccine manufacturers put mercury, lead and in some cases fluoride in vaccines. A typical case of big pharma wanting a sick population. On another note, you very rarely ever mention the effects that water fluoridation has had and remains having on our population. Fluoride is most certainly the cause of ADD and ADHD and in fact, new declassified information tells us that fluoride is not only responsible for the reduced IQ of children but there is a direct correlation between cities with fluoridated water having significantly higher levels of cancer, especially bone, thyroid and blood cancers. Hopefully you'll find out more than I have and you will offer some much needed advise on how we can rid our bodies of the accumulated fluoride which stays trapped in our thyroid and also stores itself in our bones. Check out the facts, they are absolutely appalling, it is a wonder the establishment has not faced any class action lawsuits. Thanks for listening Mike Karl's Response on 07.21.09 Dear Mike, I may well be doing more than listening. I have two quite separate thoughts for you.
I urge you to spend some HOURS reading THIS page -- the background of my not--finished Dark Times Digest Newsletter (which, eventually, will be published here). These links deal with the US FDA, but more fundamentally, with the horror which is engulfing our world -- not accidental -- but deliberate destruction of health and Western values. You'll be a bit shocked at the truth I'm revealing. It would be great, too, if you subscribe to my Premium Edition of the Dark Times Digest HERE. I have written a lot about autism, and would enjoy exchanging with you -- since I wrote about that subject many years ago. Also, I'm busy with some special projects of my own and think that my Executive Director, Clifford Woods, can help here. I'll send you the link to THIS page, invite your careful study of the links I've given above, and then your further comments. Kind Regards, Karl Loren Mike's Response, Received 07.23.09: Hi Karl, I appreciate you getting back to me so quickly. I have started reading the material you included in your reply. It is fascinating how inherently corrupt the establishment really is. Karl, be prepared to have your socks blown off. I have included a link to a blog, an interview done in France of a Canadian doctor who is the undisputed pioneer and leader in his field. His conclusive findings, if and when they ever hit mainstream, are sure to change the landscape of medicine forever. I won't carry on any farther, the interview really says it all. Let me know what you think. Mike http://censored31.skynetblogs.be/ Karl's further response on 07.23.09 Dear Mike, I did visit the web site you suggested. This man may have the magic to turn lead into gold, but he is NOT credible for reasons that may offend you. My own research and writings on heart disease and cancer are NOT less revolutionary than his stuff, but HE has to tell his story down in some dark alley. I have labored these 35 years, always very much in the public spotlight. I have not only done the revolutionary research, but published it on more than 100,000 web pages. Any fool can write and if he learns how and has the money, any fool can publish thousands of pages of junk.MOST of what I find IS JUNK .I do not write such. It is too bad, perhaps, that good ideas don't, somehow, get found easily. Not so, I have worked hard these 35 years to get my stuff into the MAIN STREAM. The best measure of a web site is "page visits" == one person visits on page at one date/time. That is "one page visit." I have gotten over 300,000 page visits on my thousands of pages EVERY MONTH, and that indicates that thousands of people are reading my stuff. Next, I put my money where my mouth is. I've designed formulas that save lives. I sell millions of dollars of this stuff, and have many customers who have bought regularly from me for more than 10 years. I am not modest about it, but there just isn't any other person in the world who comes close to me in accomplishment. Why am I not BETTER KNOWN? That is the subject of my new research and writing. THERE IS suppression on our planet -- suppression of bright good ideas. Millions of people have succumbed to those evil intentions -- and voted for Obama. I have, somehow, stayed free of those influences and prospered. The whole of my story is published and one place where you can get a taste of ME, is HERE, but do not think to brag to me, and urge me to look, about some obscure doctor who has not succeeded in the face of evil. Mike, your English sets you apart from the crowd, but you need to spend some hundreds of hours on my web sites if you want to live through these coming Dark Times and achieve "heaven" Karl Loren Mike's Response 07.23.09:Later, same day On Thu, Jul 23, 2009 at 11:28 AM, Mike Roy <mikeroy23@gmail.com> wrote:
Dear Mike, An author without a reader is a thirsty man in a desert. You do not offend me. You are obviously a well - educated person. I am eager to get through to more people about what I consider is a greater threat, by far, to our Nation, than the Obama Health Care Bill. I am certain about my data, but not yet certain how to write about my reality so as to INTEREST others -- interest comes first, then convince. So, indeed, bury your head and then let me have a "stranger/reader's" viewpoint of whatever happend? That would be great. but, you've not yet told me about yourself and your interests? Karl Loren
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